3-Bromo-2-chloro-5-methylpyridine

Base Information

• Chemical Name: 3-Bromo-2-chloro-5-methylpyridine
• CAS No.: 17282-03-0
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.469
• Hs Code.: 2933399090
• European Community (EC) Number: 829-658-4
• NSC Number: 142315
• DSSTox Substance ID: DTXSID30301315
• Wikidata: Q72517577
• Mol file: 17282-03-0.mol

Synonyms:3-bromo-2-chloro-5-methylpyridine;17282-03-0;2-Chloro-3-bromo-5-methylpyridine;3-bromo-2-chloro-5-picoline;MFCD01830664;PYRIDINE, 3-BROMO-2-CHLORO-5-METHYL-;5-bromo-6-chloro-3-picoline;3-bromo-2-chloro-5-methyl-pyridine;NSC142315;SCHEMBL761533;2-chloro-3-bromo-5-picoline;DTXSID30301315;BCP22233;CS-D0948;AKOS005258275;AB09970;DS-1330;NSC 142315;NSC-142315;AC-24921;BP-10313;SY018253;AM20070097;B5061;FT-0648077;3-Bromo-2-chloro-5-methylpyridine, AldrichCPR;EN300-159822;AE-473/30224034;J-511849

Chemical Property of 3-Bromo-2-chloro-5-methylpyridine

Chemical Property:

• Appearance/Colour: Yellow Solid
• Vapor Pressure: 0.0402mmHg at 25°C
• Melting Point: 65-68 °C
• Refractive Index: 1.571
• Boiling Point: 247.5 °C at 760 mmHg
• PKA: -0.23±0.10(Predicted)
• Flash Point: 103.5 °C
• PSA: 12.89000
• Density: 1.624 g/cm³
• LogP: 2.80590
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 204.92939
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-2-chloro-5-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 22-26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(N=C1)Cl)Br

Technology Process of 3-Bromo-2-chloro-5-methylpyridine

There total 4 articles about 3-Bromo-2-chloro-5-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-5-methylpyridin-2-amine (17282-00-7) → 3-bromo-2-chloro-5-methyl-pyridine (17282-03-0)

Guidance literature:

3-bromo-5-methylpyridin-2-amine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

With ammonia; In water;

Reference yield:

3-bromo-5-methylpyridine-2-pyridone (17282-02-9) → 3-bromo-2-chloro-5-methyl-pyridine (17282-03-0)

Guidance literature:

3-bromo-5-methylpyridine-2-pyridone; With trichlorophosphate; for 20h; Heating / reflux;

With sodium hydroxide; water; at 0 ℃; pH=8.5;

Reference yield:

2-hydroxy-3-bromo-5-methylpyridine (17282-02-9) → 3-bromo-2-chloro-5-methyl-pyridine (17282-03-0)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

3-bromo-5-methylpyridin-2-amine

2-hydroxy-3-bromo-5-methylpyridine

3-bromo-5-methylpyridine-2-pyridone

Downstream raw materials:

3-bromo-5-methyl-2-phenoxypyridine

3-bromo-2-butoxy-5-methylpyridine

5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester

8-bromo-6-methyltetrazolo[1,5-a]pyridine