2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

Base Information

Chemical Name:2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid
CAS No.:912893-81-3
Molecular Formula:C₂₁H₂₀N₂O₆
Molecular Weight:396.4
Hs Code.:

Synonyms:2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

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Chemical Property of 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

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Technology Process of 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

There total 2 articles about 2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 3343-28-0,3085-92-5
N-phthaloylglutamic acid anhydride

: 912893-81-3
2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

Guidance literature:: With pyridine; at 20 - 60 ℃; for 12.5h;
DOI:10.1021/jm020079d

Reference yield:

: 6349-98-0,2301-52-2
N-phthalylglutamic acid

: 912893-81-3
2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride; trifluoroacetic anhydride / 13 h / 100 °C

2: pyridine / 12.5 h / 20 - 60 °C

With pyridine; acetic anhydride; trifluoroacetic anhydride;
DOI:10.1021/jm020079d

Reference yield:

: 912893-81-3
2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-methoxy-benzylcarbamoyl)-butyric acid

: 222713-10-2
1-(4-methoxybenzyl)-3-(1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.11 g / acetic anhydride; trifluoroacetic anhydride / 12 h / 70 °C

2: aluminum amalgam; H₂O / tetrahydrofuran / 3 h / 20 °C

3: p-toluenosulfonic acid / CH₂Cl₂ / 15 h / 20 °C

4: 291 mg / H₂O / Raney nickel / ethanol / 5 h / 20 °C

With aluminium amalgam; water; acetic anhydride; toluene-4-sulfonic acid; trifluoroacetic anhydride; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm020079d