4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:849217-69-2
Molecular Formula:C₃₇H₃₉F₂N₅O₇
Molecular Weight:703.743
Hs Code.:

4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Synonyms:4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 849217-66-9
cyclopropane-1,1-dicarboxylic acid [3-fluoro-4-(7-hydroxy-6-methoxy-quinazolin-4-yloxy)-phenyl]-amide-(4-fluoro-phenyl)-amide

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 849217-69-2
4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 849217-58-9
N'-(3-fluoro-4-hydroxyphenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 849217-69-2
4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

2: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With hydrogen; potassium carbonate; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 168268-00-6
4-(benzyloxy)-3-fluoroaniline

: 849217-69-2
4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

3: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

5: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With cyclohexa-1,4-diene; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;