cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

Base Information

Chemical Name:cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate
CAS No.:849217-71-6
Molecular Formula:C₂HF₃O₂*C₃₂H₃₁F₂N₅O₅
Molecular Weight:717.649
Hs Code.:

cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

Synonyms:cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

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Chemical Property of cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

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Technology Process of cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

There total 13 articles about cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 849217-69-2
4-[4-(2-fluoro-4-{[1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarbonyl]-amino}-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 849217-71-6
cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 168268-00-6
4-(benzyloxy)-3-fluoroaniline

: 849217-71-6
cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

2: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

3: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

4: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

5: potassium carbonate / N,N-dimethyl-formamide / 80 °C

6: dichloromethane / 1 h / 20 °C

With cyclohexa-1,4-diene; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide;

Reference yield:

: 76243-24-8
1-(benzyloxy)-2-fluoro-4-nitrobenzene

: 849217-71-6
cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(piperidin-4-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-amide-(4-fluoro-phenyl)-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium formate; iron / water; toluene / Heating / reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

3: cyclohexa-1,4-diene / palladium 10% on activated carbon / ethanol / 2 h / Heating / reflux

4: potassium carbonate / ISOPROPYLAMIDE / 16 h / 50 °C

5: hydrogen; acetic acid / palladium 10% on activated carbon / methanol; dichloromethane / 4 h / 2068.65 Torr

6: potassium carbonate / N,N-dimethyl-formamide / 80 °C

7: dichloromethane / 1 h / 20 °C

With cyclohexa-1,4-diene; hydrogen; ammonium formate; iron; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;