4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

Base Information

Chemical Name:4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene
CAS No.:261958-58-1
Molecular Formula:C₂₉H₃₄Cl₂O₉
Molecular Weight:597.49
Hs Code.:

Synonyms:4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

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Chemical Property of 4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

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Technology Process of 4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

There total 13 articles about 4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 261958-52-5
3,5-bis(methoxymethoxy)-4-bromo-2,6-dichlorotoluene

: 261958-51-4
2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)benzaldehyde

: 261958-58-1
4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/S0040-4039(99)02005-5

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 261958-58-1
4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

Guidance literature:: Multi-step reaction with 9 steps

1: 87 percent / DIPEA / CH₂Cl₂ / 5 h / 0 - 20 °C

2: 98 percent / LiAlH₄ / diethyl ether / 2 h / 0 - 20 °C

3: 93 percent / N-bromosuccinimide / dimethylformamide / 2 h / 0 °C

4: 95 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C

5: 95 percent / n-BuLi / hexane; diethyl ether / 3 h / -78 - 20 °C

6: 94 percent / aq. HCl / tetrahydrofuran / 2 h / 20 °C

7: 72 percent / K₂CO₃ / acetone / 1 h / 20 °C

8: 90 percent / Cs₂CO₃ / dimethylformamide / 1 h / 20 °C

9: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; sodium hydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)01250-9

Reference yield:

: 63992-61-0
4,6-dichloro-5-methylresorcinol

: 261958-58-1
4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Br₂ / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

2: 100 percent / DIPEA / CH₂Cl₂ / 1 h / 20 °C

3: 86 percent / n-BuLi / tetrahydrofuran; hexane / 3.25 h / -78 - 20 °C

With n-butyllithium; bromine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)01250-9