261958-52-5

Upstream product

• 504-15-4 orcinol 
• 63992-61-0 4,6-dichloro-5-methylresorcinol 
• 107-30-2 chloromethyl methyl ether 
• 261958-57-0 2-bromo-4,6-dichloro-5-methylbenzene-1,3-diol 

Downstream Products

• 261958-57-0 2-bromo-4,6-dichloro-5-methylbenzene-1,3-diol 
• 1026582-55-7 [3,5-bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(3-methyl-but-2-enyl)-phenyl]-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-phenyl)-methanol 
• 261958-59-2 2'-benzyloxymethyl-6'-methoxy-2,4',6-tris(methoxymethoxy)-3,5-dichloro-4-methylbenzophenone 
• 261958-63-8 methyl 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzoate 
• 261958-62-7 2-(3,5-dichloro-2,6-bis-methoxymethoxy-4-methyl-benzoyl)-3-methoxy-5-methoxymethoxy-benzoic acid 
• 261958-60-5 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzyl alcohol 
• 261958-61-6 2-[2,6-bis(methoxymethoxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-5-(methoxymethoxy)benzaldehyde 
• 2151-16-8 methyl 2-(3,5-dichloro-2,6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate 
• 261958-58-1 4-{[2-benzyloxymethyl-6-methoxy-4-(methoxymethoxy)phenyl]hydroxymethyl}-3,5-bis(methoxymethoxy)-2,6-dichlorotoluene 

Relevant academic research and scientific papers

Synthetic analogues of the antibiotic pestalone

The first synthetic study towards the natural product pestalone (1) is described culminating in the preparation of selected n-1 analogues. Pestalone is a chlorinated and prenylated benzophenone antibiotic, which is of interest due to a strong activity aga

Synthetic studies on Sch 202596, an antagonist of the galanin receptor subtype GalR1: An efficient synthesis of (±)-geodin, the spirocoumaranone part of Sch 202596

An efficient and facile synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone part of Sch 202596 (1) was accomplished in a convergent manner. The synthetic method features (i) a coupling reaction of the aryl aldehyde 6 with the aryl lithium 7 generated in situ from the aryl bromide 8 to deliver the highly substituted diaryl methanol 24 (6+7→24) and ii) oxidative spirocyclization reaction of the benzophenone 4 to construct the requisite spirocoumaranone skeleton [4→(±)-2] as the key steps. The aromatic segments 6 and 8 were prepared from commercially available methyl 3,5-dihydroxybenzoate (9) and 5-methylresorcinol (10), respectively.

Studies toward the total synthesis of Sch 202596, an antagonist of the galanin receptor subtype GalR1: Synthesis of geodin, the spirocoumaranone subunit of Sch 202596

An efficient synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone subunit of Sch 202596 (1) was accomplished in a convergent manner by utilizing coupling reaction of the aryl aldehyde 5 with the aryl bromide 6 and oxidative spirocyclization of the benzophenone 4 as the key steps. The aromatic segments 5 and 6 were prepared from commercially available methyl 3,5-dihydroxybenzoate (7) and 5-methylresorcinol (8), respectively.