N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester

Base Information

• Chemical Name: N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester
• CAS No.: 89637-93-4
• Molecular Formula: C₆₇H₈₆N₁₄O₁₄
• Molecular Weight: 1311.51

Synonyms:N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester

Chemical Property of N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester

There total 7 articles about N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Nα-(tert-Butyloxycarbonyl)-Nε-10-methylpteroyl)-γ-L-glutamyl>-L-lysine Benzyl (Oα-glu) Ester (89106-06-9) + (S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester; compound with toluene-4-sulfonic acid (89637-89-8) → Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-Nε-(benzyloxycarbonyl)-L-lysyl-Nε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester (89637-93-4)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm00373a014

Reference yield:

1-benzyl L-glutamate (13030-09-6) → Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-Nε-(benzyloxycarbonyl)-L-lysyl-Nε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester (89637-93-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: 1.) diethyl phosphorocyanidate, Et₃N / 1.) DMF, overnight, RT, 2.) DMF, RT, 3 d

3: Et₃N / dimethylformamide / 0.33 h / Ambient temperature

4: dimethylformamide / Ambient temperature

5: 74 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

With diethyl cyanophosphonate; diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00373a014

Reference yield:

Boc-Lys-OH (13734-28-6) → Nα-(tert-butyloxycarbonyl)-Nε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-Nε-(benzyloxycarbonyl)-L-lysyl-Nε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester (89637-93-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / Et₃N / benzene / Ambient temperature

2: dimethylformamide / Ambient temperature

3: 74 percent / diphenylphosphoryl azide, Et₃N / dimethylformamide / 0 - 20 °C

With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00373a014

upstream raw materials:

N^α-(tert-Butyloxycarbonyl)-N^ε-10-methylpteroyl)-γ-L-glutamyl>-L-lysine Benzyl (O^α-glu) Ester

(S)-2-((S)-2-Amino-6-benzyloxycarbonylamino-hexanoylamino)-6-benzyloxycarbonylamino-hexanoic acid methyl ester; compound with toluene-4-sulfonic acid

1-benzyl L-glutamate

Boc-Lys-OH

Downstream raw materials:

N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 89637-93-4 N^α-(tert-butyloxycarbonyl)-N^ε-10-methylpteroyl)-L-γ-glutamyl>-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysyl-N^ε-(benzyloxycarbonyl)-L-lysine benzyl(α-Glu)methyl(Lys) ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send