(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

Base Information

Chemical Name:(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide
CAS No.:1538580-79-8
Molecular Formula:C₂₂H₂₃FN₂OS
Molecular Weight:382.502
Hs Code.:

Synonyms:(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

Suppliers and Price of (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

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Technology Process of (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

There total 2 articles about (Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 49627-27-2
sulindac sulfide

: 107-15-3,85404-18-8
ethylenediamine

: 1538580-79-8
(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

Guidance literature:: sulindac sulfide; With 1,1'-carbonyldiimidazole; In dichloromethane; for 6h; Inert atmosphere;

ethylenediamine; In dichloromethane; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.014

Reference yield:

: 38194-50-2
Sulindac

: 1538580-79-8
(Z)-N-(2-aminoethyl)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium tetrachloride; zinc / dichloromethane; tetrahydrofuran / 2.5 h / Cooling with acetone-dry ice; Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 6 h / Inert atmosphere

2.2: Inert atmosphere

With titanium tetrachloride; 1,1'-carbonyldiimidazole; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2013.12.014