Ac-LYRAA-SCH₂CH₂COOCH₃

Base Information

• Chemical Name: Ac-LYRAA-SCH₂CH₂COOCH₃
• CAS No.: 1613402-34-8
• Molecular Formula: C₃₃H₅₂N₈O₉S
• Molecular Weight: 736.89
• Mol file: 1613402-34-8.mol

Synonyms:Ac-LYRAA-SCH₂CH₂COOCH₃

Chemical Property of Ac-LYRAA-SCH₂CH₂COOCH₃

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-LYRAA-SCH₂CH₂COOCH₃

There total 1 articles about Ac-LYRAA-SCH₂CH₂COOCH₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Ala-O-Wang resin + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + acetic anhydride (108-24-7) → Ac-LYRAA-SCH2CH2COOCH3 (1613402-34-8)

Guidance literature:

Fmoc-Ala-O-Wang resin; With piperidine; In N,N-dimethyl-formamide; ? TG amino resin

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methylmorpholine N-oxide; In N,N-dimethyl-formamide; ? TG amino resin

Fmoc-Leu-OH; acetic anhydride; Fmoc-Arg(pg)-OH; Fmoc-Tyr(pg)-OH; Further stages;

DOI:10.1016/j.tetlet.2014.04.102

Reference yield: 84.0%

H-CRANK-NH2 (271795-10-9) + Ac-LYRAA-SCH2CH2COOCH3 (1613402-34-8) → Ac-LYRAACRANK-NH2 (1613402-41-7)

Guidance literature:

With 1-ethyl-3-methylimidazolium acetate; at 20 ℃; for 1h; Reagent/catalyst; Time; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.04.102

Reference yield:

H-CRANK-NH2 (271795-10-9) + Ac-LYRAA-SCH2CH2COOCH3 (1613402-34-8) → Ac-LYRAACRANK-NH2 (1613402-41-7) + C55H93N19O15S2 + C51H87N19O15S

Guidance literature:

With 1-ethyl-3-methylimidazolium acetate; at 20 ℃; for 4h; Reagent/catalyst; Time; Overall yield = 78%; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.04.102

upstream raw materials:

Fmoc-Leu-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

acetic anhydride

Downstream raw materials:

Ac-LYRAACRANK-NH₂