2-(2-Methoxyphenyl)-2-oxoacetic acid

Base Information

• Chemical Name: 2-(2-Methoxyphenyl)-2-oxoacetic acid
• CAS No.: 26767-06-6
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• DSSTox Substance ID: DTXSID001299644
• Nikkaji Number: J2.950.971I
• ChEMBL ID: CHEMBL131413
• Mol file: 26767-06-6.mol

Synonyms:2-(2-methoxyphenyl)-2-oxoacetic acid;26767-06-6;2-Methoxybenzoylformic acid;2-methoxyphenylglyoxylic acid;CHEMBL131413;SCHEMBL4621633;(2-methoxyphenyl)oxoacetic acid;RGOJMRLSECAMJM-UHFFFAOYSA-N;(2-methoxyphenyl)(oxo)acetic acid;DTXSID001299644;2-(2-Methoxyphenyl)glyoxylic acid;BBA76706;(2-Methoxy-phenyl)-oxo-acetic acid;2-(2-methoxyphenyl)-2-oxoaceticacid;2-Methoxy-alpha-oxobenzeneacetic acid;AKOS022300679;AT10835;CS-0308849;EN300-136020;Z1255489035

Chemical Property of 2-(2-Methoxyphenyl)-2-oxoacetic acid

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 180.04225873
• Heavy Atom Count: 13
• Complexity: 212

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(=O)C(=O)O

Technology Process of 2-(2-Methoxyphenyl)-2-oxoacetic acid

There total 11 articles about 2-(2-Methoxyphenyl)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl (2-methoxyphenyl)(oxo)acetate (66644-69-7) → 2-(2-methoxyphenyl)-2-oxoacetic acid (26767-06-6)

Guidance literature:

With sodium hydroxide; In water; for 1.5h; Heating;

DOI:10.3987/COM-15-S(T)14

Reference yield: 60.0%

2-Methoxyacetophenone (579-74-8) → 2-(2-methoxyphenyl)-2-oxoacetic acid (26767-06-6)

Guidance literature:

With pyridine; selenium(IV) oxide; at 80 ℃; for 4h;

DOI:10.3762/bjoc.6.121

Reference yield:

o-methoxymandelic acid (10408-29-4,89709-23-9) → 2-(2-methoxyphenyl)-2-oxoacetic acid (26767-06-6)

Guidance literature:

With potassium permanganate; sodium hydroxide; In water; at -4 - 0 ℃; for 2h;

DOI:10.1055/s-0033-1339348

upstream raw materials:

2-(2-methoxy-phenyl)-3-methyl-crotonic acid

2-Methoxyacetophenone

methyl 2-(2-methoxyphenyl)-2-oxoacetate

methyl (+/-)-α-hydroxy-α-(2-methoxyphenyl)acetate

Downstream raw materials:

2-(2-methoxyphenyl)-2-oxoacetyl chloride

S-t-butyl (2-methoxyphenyl)-oxo-thioacetate

S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate

1-benzofurane