S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate

Base Information

• Chemical Name: S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate
• CAS No.: 959161-45-6
• Molecular Formula: C₁₃H₁₈O₃S
• Molecular Weight: 254.35
• Mol file: 959161-45-6.mol

Synonyms:S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate

Chemical Property of S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate

There total 5 articles about S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S-t-butyl (2-methoxyphenyl)-oxo-thioacetate (959161-63-8) → S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate (959161-45-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran;

DOI:10.1021/jo070575f

Reference yield:

2-(2-methoxyphenyl)-2-oxoacetyl chloride (1011297-70-3) → S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate (959161-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 0 - 20 °C

2: sodium borohydride / tetrahydrofuran

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo070575f

Reference yield:

methyl 2-(2-methoxyphenyl)-2-oxoacetate (5180-78-9) → S-t-butyl hydroxy-(2-methoxy-phenyl)-thioacetate (959161-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1: KOH / H₂O; ethanol

2: oxalyl chloride / CH₂Cl₂ / 0.5 h / cooling

3: triethylamine / CH₂Cl₂ / 0 - 20 °C

4: sodium borohydride / tetrahydrofuran

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jo070575f

upstream raw materials:

S-t-butyl (2-methoxyphenyl)-oxo-thioacetate

2-(2-methoxyphenyl)-2-oxoacetyl chloride

methyl 2-(2-methoxyphenyl)-2-oxoacetate

2-(2-methoxyphenyl)-2-oxoacetic acid

Downstream raw materials:

S-t-butyl (2-methoxyphenyl)-oxo-thioacetate