Methyl 2-(2-methoxyphenyl)-2-oxoacetate

Base Information

• Chemical Name: Methyl 2-(2-methoxyphenyl)-2-oxoacetate
• CAS No.: 5180-78-9
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol file: 5180-78-9.mol

Synonyms:Methyl 2-(2-methoxyphenyl)-2-oxoacetate

Chemical Property of Methyl 2-(2-methoxyphenyl)-2-oxoacetate

Chemical Property:

• PSA: 52.60000
• LogP: 1.05090

Purity/Quality:

99% ^*data from raw suppliers

METHYL2-(2-METHOXYPHENYL)-2-OXOACETATE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(2-methoxyphenyl)-2-oxoacetate

There total 9 articles about Methyl 2-(2-methoxyphenyl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 2-(2-methoxyphenyl)acetate (27798-60-3) → methyl 2-(2-methoxyphenyl)-2-oxoacetate (5180-78-9)

Guidance literature:

With tert.-butylhydroperoxide; vanadium pillared montmorillonite catalyst (V-PILC); In 2,2,4-trimethylpentane; benzene; at 70 ℃; for 20h;

DOI:10.1039/c39930000323

Reference yield: 76.0%

methyl α-diazo-α-(2-methoxyphenyl)acetate (347187-58-0) → methyl 2-(2-methoxyphenyl)-2-oxoacetate (5180-78-9)

Guidance literature:

With copper nanoparticles on activated carbon; oxygen; In 1,2-dichloro-ethane; at 30 ℃; for 36h; Schlenk technique;

DOI:10.1039/d1ob00811k

Reference yield: 37.0%

N-trimethylsilylmethylamine (18166-02-4) + carbon dioxide (124-38-9,18923-20-1) + (2-methoxyphenyl)(trimethylsilyl)methanone (107325-71-3) → methyl 2-(2-methoxyphenyl)-2-oxoacetate (5180-78-9)

Guidance literature:

carbon dioxide; (2-methoxyphenyl)(trimethylsilyl)methanone; With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 24h; under 760.051 Torr; Schlenk technique; Sealed tube; Irradiation;

N-trimethylsilylmethylamine; In methanol; diethyl ether; hexane; dimethyl sulfoxide; at 0 ℃; for 0.5h; under 760.051 Torr; Schlenk technique; Sealed tube; Irradiation;

DOI:10.1021/acs.orglett.1c00435

upstream raw materials:

methyl 2-(2-methoxyphenyl)acetate

methyl 2,2-dichloro-2-methoxyacetate

methoxybenzene

methyl (+/-)-α-hydroxy-α-(2-methoxyphenyl)acetate

Downstream raw materials:

2-(2-methoxyphenyl)-2-oxoacetic acid

(S)-2-hydroxy-2-(2-methoxyphenyl)acetic acid