BOC-GLU(OBZL)-OME

Base Information

• Chemical Name: BOC-GLU(OBZL)-OME
• CAS No.: 59279-58-2
• Molecular Formula: C18H25 N O6
• Molecular Weight: 351.4
• DSSTox Substance ID: DTXSID40552977
• Wikidata: Q82433426
• Mol file: 59279-58-2.mol

Synonyms:BOC-GLU(OBZL)-OME;BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-METHYL ESTER;BOC-L-GLUTAMIC ACID-GAMMA-BENZYL ALPHA-METHYL-DIESTER;N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-METHYL ESTER;Boc-L-glutamic acid γ-benzyl α-methyl ester;Boc-L-glutamicacid-benzyla-methylester;BOC-L-GLUTAMIC ACID-Y-BENZYL A-METHYL-DIESTER;BOC-L-GLUTAMIC ACID .GAMMA.-BENZYL .ALPHA.-METHYL ESTER

Chemical Property of BOC-GLU(OBZL)-OME

Chemical Property:

• PSA: 90.93000
• LogP: 2.96720
• Storage Temp.: Store at 0°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 11
• Exact Mass: 351.16818752
• Heavy Atom Count: 25
• Complexity: 451

Purity/Quality:

97% ^*data from raw suppliers

Boc-Glu(Obzl)-OMe 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC(CCC(=O)OCC1=CC=CC=C1)C(=O)OC
• Isomeric SMILES: CC(C)(C)OC(=O)N[C@@H](CCC(=O)OCC1=CC=CC=C1)C(=O)OC

Technology Process of BOC-GLU(OBZL)-OME

There total 10 articles about BOC-GLU(OBZL)-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + Boc-Glu(OBzl)-OH (13574-13-5) → Nα-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester (59279-58-2)

Guidance literature:

With diazomethyl-trimethyl-silane; In hexane; dichloromethane; at 0 - 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2018.12.044

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Boc-Glu(OBzl)-OH (13574-13-5) → Nα-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester (59279-58-2)

Guidance literature:

In diethyl ether; ethanol; at 65 ℃; for 0.333333h;

DOI:10.1039/b702076g

Reference yield: 95.0%

Boc-Glu(OBzl)-OH (13574-13-5) + dimethyl sulfate (77-78-1) → Nα-tert-butyloxycarbonyl-γ-benzyloxycarbonyl-L-glutamic acid methyl ester (59279-58-2)

Guidance literature:

Boc-Glu(OBzl)-OH; With potassium carbonate; In acetone; for 0.166667h; Inert atmosphere;

dimethyl sulfate; In acetone; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.02.089

upstream raw materials:

diazomethane

Boc-Glu(OBzl)-OH

diazomethyl-trimethyl-silane

methanol

Downstream raw materials:

N-(tert-butoxycarbonyl)-D-seryl-L-glutamic acid 1-methyl 5-benzyl diester

-L-glutamic acid 1-methyl 5-benzyl diester

-L-glutamic acid 1-methyl 5-benzyl diester

methyl (S)-(-)-Δ¹-2-(2-hydroxyphenyl)-5-pyrrolinecarboxylate