Technology Process of ethyl (1S,2R)-5,5-difluoro-2-({[4-(3-methyl-1H-pyrazol-1-yl)phenyl]carbonyl}amino)cyclohexanecarboxylate
There total 9 articles about ethyl (1S,2R)-5,5-difluoro-2-({[4-(3-methyl-1H-pyrazol-1-yl)phenyl]carbonyl}amino)cyclohexanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
acetonitrile;
at 20 ℃;
for 12h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C
1.2: 2 h / 0 - 10 °C
2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere
3.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice
4.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice
5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice
5.2: 20 °C / Cooling with ice
6.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C
7.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 12 h / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; water; acetone; toluene; isobutyric Acid; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene-4-sulfonic acid / toluene / 17 h / 70 °C / Reflux
2.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C
2.2: 2 h / 0 - 10 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere
4.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice
5.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice
6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice
6.2: 20 °C / Cooling with ice
7.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C
8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 12 h / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; water; acetone; toluene; isobutyric Acid; acetonitrile;
