ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Base Information

Chemical Name:ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate
CAS No.:1092728-64-7
Molecular Formula:C₉H₁₅F₂NO₂
Molecular Weight:207.22
Hs Code.:

Synonyms:ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Suppliers and Price of ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

There total 7 articles about ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092728-42-1
ethyl (1S,2R)-2-{[(benzyloxy)carbonyl]amino}-5,5-difluorocyclohexanecarboxylate

: 1092728-64-7
ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; water; at 20 ℃; for 4h;

Reference yield:

: 813445-18-0
ethyl (R)-8-((1-phenylethyl)amino)-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1092728-64-7
ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

1.2: 2 h / 0 - 10 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

3.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

4.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice

5.2: 20 °C / Cooling with ice

6.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium carbonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; acetone; toluene; isobutyric Acid;

Reference yield:

: 121210-56-8
ethyl 8-hydroxy-1,4-dioxaspiro[4.5]dec-7-ene-7-carboxylate

: 1092728-64-7
ethyl (1S,2R)-2-amino-5,5-difluorocyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / toluene / 17 h / 70 °C / Reflux

2.1: sodium tetrahydroborate / isobutyric Acid / 0 - 20 °C

2.2: 2 h / 0 - 10 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 5 h / 50 °C / Inert atmosphere

4.1: sodium carbonate / water; tetrahydrofuran / 20 °C / Cooling with ice

5.1: hydrogenchloride / water; acetone / 20 °C / Cooling with ice

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 20 °C / Cooling with ice

6.2: 20 °C / Cooling with ice

7.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 4 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium carbonate; toluene-4-sulfonic acid; (bis-(2-methoxyethyl)amino)sulfur trufluoride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water; acetone; toluene; isobutyric Acid;