<6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone

Base Information

• Chemical Name: <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone
• CAS No.: 84449-87-6
• Molecular Formula: C₂₉H₂₉NO₄S
• Molecular Weight: 487.62
• Mol file: 84449-87-6.mol

Synonyms:<6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone

Chemical Property of <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone

There total 8 articles about <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-hexamethyleneiminoethoxy)benzoyl]benzo[b]thiophene, hydrochloride (84449-72-9) → <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone (84449-87-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1021/jm00374a021

Reference yield:

α-(3-methoxyphenyl-thio)-4-methoxyacetophenone (63675-73-0) → <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone (84449-87-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 69 percent / PPA / 1 h / 85 - 90 °C

2: 71 percent / pyridine hydrochloride / 6 h / 220 °C

3: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature

4: 73 percent / AlCl₃ / 1,2-dichloro-ethane / 16 h

5: 38 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating

With pyridine; dmap; sodium hydroxide; aluminium trichloride; pyridine hydrochloride; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm00374a021

Reference yield:

3-methoxybenzenethiol (15570-12-4) → <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone (84449-87-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 80.4 percent / KOH / ethanol; H₂O; ethyl acetate / Ambient temperature

2: 69 percent / PPA / 1 h / 85 - 90 °C

3: 71 percent / pyridine hydrochloride / 6 h / 220 °C

4: 99 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature

5: 73 percent / AlCl₃ / 1,2-dichloro-ethane / 16 h

6: 38 percent / 5 N aq. NaOH / ethanol / 1.5 h / Heating

With pyridine; dmap; potassium hydroxide; sodium hydroxide; aluminium trichloride; pyridine hydrochloride; In ethanol; water; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jm00374a021

upstream raw materials:

6-methanesulfonyloxy-2-(4-methanesulfonyloxyphenyl)-3-[4-(2-hexamethyleneiminoethoxy)benzoyl]benzo[b]thiophene, hydrochloride

3-methoxybenzenethiol

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene

Refernces

• 1、 -. "Process for preparing benzo[b]thiophenes". . . Retrieved 2008/06/13.
• 2、 -. "Amorphous benzothiophenes, methods of preparation, and methods of use". . . Retrieved 2008/06/13.