63675-73-0

Basic information

• Product Name: 4-METHOXY-A-((3-METHOXY PHENYL)THIO)ACETOPHENONE
• Synonyms: 4-METHOXY-ALPHA-[(3-METHOXYPHENYL)THIO]ACETOPHENONE;4-METHOXY-A-((3-METHOXY PHENYL)THIO)ACETOPHENONE;4-METHOXY-[(3-METHOXYPHENYL)THIO]ACETOPHENONE;4-Methoxy-A-[(3-Methoxyphenyl)Thiol]Acetophenone;1-(4-METHOXYPHENYL)-2-(3-MEETHOXYPHENYLTHIO)ETHANONE;2-(3,4-dimethoxyphenylthio)-1-phenylethanone;4-Methoxy-à-[(3-Methoxyphenyl)thio]Acetophenone;1-(4-Methoxyphenyl)-2-(3-methoxyphenylthio)ethanone
• CAS NO: 63675-73-0
• Molecular Formula: C₁₆H₁₆O₃S
• Molecular Weight: 288.36
• Mol File: 63675-73-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 407.464°C at 760 mmHg
• Flash Point: 198.084°C
• Appearance: /
• Density: 1.235g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-METHOXY-A-((3-METHOXY PHENYL)THIO)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-A-((3-METHOXY PHENYL)THIO)ACETOPHENONE(63675-73-0)
• EPA Substance Registry System: 4-METHOXY-A-((3-METHOXY PHENYL)THIO)ACETOPHENONE(63675-73-0)

Safety Data

• Hazardous Substances Data: 63675-73-0(Hazardous Substances Data)

Usage

Uses

1-(4-Methoxyphenyl)-2-((3-methoxyphenyl)-thio)ethanone (CAS# 63675-73-0) is a building block/intermediate useful towards the synthesis of Raloxifene (R100000) and other benzothiophene-containing structures. It is also useful in the preparation of estrogen receptor targeting antagonists for treatment of proliferative diseases including cancer, particularly breast cancer.

InChI:InChI=1/C15H14O3S/c1-17-12-8-6-11(7-9-12)15(16)19-14-5-3-4-13(10-14)18-2/h3-10H,1-2H3

Upstream product

• 153163-79-2 chloromethoxyacetophenone 
• 15570-12-4 3-methoxybenzenethiol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 59014-89-0 bis(3-methoxyphenyl)disulfide 
• 21875-72-9 1-(4-methoxy-phenyl)-2-phenylsulfanyl-ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 63675-74-1 2-(4'-methoxyphenyl)-6-methoxybenzothiophene 
• 90433-54-8 2-(4'-methoxyphenyl)-4-methoxybenzo[b]thiophene 
• 1657-55-2 1,2-bis(4-methoxyphenyl)ethane 
• 63676-25-5 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene 
• 84449-90-1 Raloxifen 
• 63676-22-2 6-hydroxy-2-(4-hydroxyphenyl)benzo[B]-thiophene 
• 84449-63-8 6-acetoxy-2-(4-acetoxyphenyl)benzo[b]thiophene 
• 84449-65-0 6-<(methylsulfonyl)oxy>-2-<4-<(methylsulfonyl)oxy>phenyl>benzothiophene 
• 84449-86-5 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-dimethylamino-ethoxy)benzoyl]benzo[B]thiophene 
• 84449-64-9 6-(benzoyloxy)-2-<4-(benzoyloxy)phenyl>benzothiophene 
• 84449-96-7 <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(diethylamino)ethoxy>phenyl>methanone 
• 84449-88-7 <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-ethoxy>phenyl>methanone 
• 84449-87-6 <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-hexahydroazepinyl)ethoxy>phenyl>methanone 
• 82640-04-8 raloxifene hydrochloride 

Relevant articles and documents

A new anti-tubulin agent containing the benzo[b]thiophene ring system

A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6- methoxybenzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.

Facile synthesis of 3-aryl benzofurans, 3-aryl benzothiophenes, 2-aryl indoles and their dimers

The preparation of 3-aryl benzofuran and benzothiophenes and their dimers at 2-position and, 2-aryl indoles and their 3-position dimers preparation is described.

Discovery of a New Class of Liver Receptor Homolog-1 (LRH-1) Antagonists: Virtual Screening, Synthesis and Biological Evaluation

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