Technology Process of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)quinolin-4(1H)-one
There total 8 articles about 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-3-(pyrrolidin-1-ylmethyl)quinolin-4(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 3h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 1 h / 2585.81 Torr
2.1: hydrogenchloride; sodium nitrite / water / 5 h / 20 - 45 °C / Inert atmosphere
3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
4.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux
5.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere
5.2: 3.5 h / -40 °C / Inert atmosphere
6.1: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere
7.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 20 °C / Inert atmosphere
With
hydrogenchloride; manganese(IV) oxide; palladium on activated charcoal; water; hydrogen; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; triethylamine; potassium iodide; potassium hydroxide; sodium nitrite; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
2.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux
3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere
3.2: 3.5 h / -40 °C / Inert atmosphere
4.1: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere
5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 3 h / 20 °C / Inert atmosphere
With
manganese(IV) oxide; water; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; isobutyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;