5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

Base Information

Chemical Name:5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde
CAS No.:1429439-26-8
Molecular Formula:C₂₈H₂₆ClNO₆
Molecular Weight:507.971
Hs Code.:

Synonyms:5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

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Chemical Property of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

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Technology Process of 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

There total 7 articles about 5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1429439-25-7
5-chloro-1-ethyl-3-(hydroxymethyl)-6,7-bis((4-methoxybenzyl)oxy)quinolin-4(1H)-one

: 1429439-26-8
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

Guidance literature:: With manganese(IV) oxide; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 80104-60-5
5-chloro-6,7-dihydroxy-1,4-dihydro-1-ethyl-4-oxoquinoline-3-carboxylic acid

: 1429439-26-8
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

2.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

3.2: 3.5 h / -40 °C / Inert atmosphere

4.1: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere

With manganese(IV) oxide; water; potassium carbonate; triethylamine; potassium iodide; potassium hydroxide; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 14698-29-4
oxolinic Acid

: 1429439-26-8
5-chloro-1-ethyl-6,7-bis((4-methoxybenzyl)oxy)-4-oxo-1,4-dihydroquinolin-3-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; potassium nitrate / 1 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogenchloride; palladium on activated charcoal; hydrogen; acetic acid / 1 h / 2585.81 Torr

3.1: hydrogenchloride; sodium nitrite / water / 5 h / 20 - 45 °C / Inert atmosphere

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

5.1: water; potassium hydroxide / methanol / 1.5 h / Inert atmosphere; Reflux

6.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

6.2: 3.5 h / -40 °C / Inert atmosphere

7.1: manganese(IV) oxide / dichloromethane / 20 °C / Inert atmosphere

With hydrogenchloride; manganese(IV) oxide; sulfuric acid; palladium on activated charcoal; water; hydrogen; potassium carbonate; acetic acid; potassium nitrate; triethylamine; potassium iodide; potassium hydroxide; sodium nitrite; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;