5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

Base Information

Chemical Name:5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester
CAS No.:205752-52-9
Molecular Formula:C₃₀H₃₇N₂O₁₀P
Molecular Weight:616.605
Hs Code.:

Synonyms:5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

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Chemical Property of 5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

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Technology Process of 5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

There total 6 articles about 5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 205752-51-8
6-Hydroxy-hexanoic acid 4-methoxy-benzyl ester

: 205752-50-7
5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid

: 205752-52-9
5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.46.518

Reference yield:

: 1191-25-9
6-Hydroxyhexanoic acid

: 205752-52-9
5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide / Ambient temperature

2: 98 percent / diisopropyl azopdicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.518

Reference yield:

: 4202-14-6
dimethyl (2-oxopropyl)phosphonate

: 205752-52-9
5-(Dimethoxy-phosphoryl)-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 5-(4-methoxy-benzyloxycarbonyl)-pentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / TFA / toluene / 2 h / Ambient temperature

2: 51 percent / propan-2-ol / 18 h / Heating

3: 98 percent / 1 M NaOH / acetone / 3 h / Ambient temperature

4: 98 percent / diisopropyl azopdicarboxylate, PPh₃ / tetrahydrofuran / Ambient temperature

With sodium hydroxide; di-isopropyl azodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; isopropyl alcohol; acetone; toluene;
DOI:10.1248/cpb.46.518