dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

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Chemical Name:dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate
CAS No.:104568-72-1
Molecular Formula:C₂₂H₂₆FNO₆
Molecular Weight:419.45
Hs Code.:

Synonyms:dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

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Chemical Property of dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

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Technology Process of dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

There total 7 articles about dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 104568-93-6
N-<2-(1,3-dioxolan-2-yl)ethyl>-N-(4-fluorobenzoyl)-DL-valine

: 762-42-5
dimethyl acetylenedicarboxylate

: 104568-72-1
dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

Guidance literature:: With acetic anhydride; for 2h; Ambient temperature;
DOI:10.1021/jm00105a056

Reference yield: 54.0%

: 18742-02-4
2-bromo-2-(2-ethyl)dioxolane

: 1629159-64-3
C₁₇H₁₈FNO₄

: 104568-72-1
dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

Guidance literature:: C₁₇H₁₈FNO₄; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Schlenk technique; Inert atmosphere;

2-bromo-2-(2-ethyl)dioxolane; In N,N-dimethyl-formamide; at 100 ℃; for 30h; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.201400602

Reference yield:

: 5754-35-8
2-[1,3]dioxolan-2-yl-ethylamine

: 104568-72-1
dimethyl 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrole-3,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / triethylamine / acetonitrile / 20 h / Heating

2: triethylamine / CH₂Cl₂ / 1.) 0 deg C, 50 min, 2.) RT, 60 min

3: NaOH / methanol; H₂O / 3 h / Heating

4: 89 percent / acetic anhydride / 2 h / Ambient temperature

With sodium hydroxide; acetic anhydride; triethylamine; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00105a056