(S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester

Base Information

• Chemical Name: (S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester
• CAS No.: 865086-27-7
• Molecular Formula: C₁₄H₁₇NO₅
• Molecular Weight: 279.293

Synonyms:(S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester

Chemical Property of (S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester

There total 2 articles about (S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzylidene-carbamic acid methyl ester (27593-61-9) + acetoacetic acid methyl ester (105-45-3) → (S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester (865086-27-7)

Guidance literature:

cinchonine; In dichloromethane; at -35 ℃; for 16h; Product distribution / selectivity;

Reference yield:

benzylidene-carbamic acid methyl ester (27593-61-9) + acetoacetic acid methyl ester (105-45-3) → (R)-2-((S)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester + (S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester (865086-27-7) + 2-(methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester

Guidance literature:

With Cinchonin; In dichloromethane; at -35 ℃; for 16h; Title compound not separated from byproducts;

DOI:10.1021/ja0537373

Reference yield: 95.0%

(S)-2-((R)-methoxycarbonylamino-phenyl-methyl)-3-oxo-butyric acid methyl ester (865086-27-7) + benzylamine (100-46-9) → (Z)-3-benzylamino-2-((S)-methoxycarbonylamino-phenyl-methyl)-but-2-enoic acid methyl ester

Guidance literature:

ytterbium(III) triflate; In trimethyl orthoformate; for 4h; Product distribution / selectivity;

upstream raw materials:

benzylidene-carbamic acid methyl ester

acetoacetic acid methyl ester

Downstream raw materials:

(2S,3R)-3-hydroxy-2-((R)-methoxycarbonylamino-phenyl-methyl)-butyric acid methyl ester

(2S,3R)-2-((R)-amino-phenyl-methyl)-3-hydroxy-butyric acid methyl ester

(2S,3R)-2-((R)-amino-phenyl-methyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyric acid methyl ester

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