(S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester
CAS No.:156589-19-4
Molecular Formula:C₁₉H₂₄N₂O₉
Molecular Weight:424.408
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

There total 7 articles about (S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 156589-18-3
(S)-2-tert-Butoxycarbonylamino-succinic acid bis-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

: 156589-19-4
(S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

Guidance literature:: With lithium hydroxide; In water; acetone; for 2h; 0 deg C, 2 h and 0,5 h, room t.;
DOI:10.1055/s-1993-26039

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-2-Amino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester; hydrochloride

: 156589-19-4
(S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; for 2h; Ambient temperature; pH 9;
DOI:10.1055/s-1993-26039

Reference yield:

: 60-12-8
2-phenylethanol

: 156589-19-4
(S)-2-tert-Butoxycarbonylamino-succinic acid 4-[2-(4-acetyl-2-nitro-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1: 60 percent / AlCl₃ / CH₂Cl₂ / in ice bath, 30 min and 1 h, room t.

2: 60 percent / fuming HNO₃, 96percent H₂SO₄ / acetic anhydride / 1 h / -20 °C

3: 77 percent / conc. aq. HCl/MeOH / 2 h / 50 - 60 °C

4: 68 percent / DCC/DMAP / CH₂Cl₂ / 2 h, 0 deg C and room t. overnight

5: 76 percent / LiOH*H₂O / acetone; H₂O / 2 h / 0 deg C, 2 h and 0,5 h, room t.

With hydrogenchloride; methanol; dmap; lithium hydroxide; aluminium trichloride; sulfuric acid; nitric acid; dicyclohexyl-carbodiimide; In dichloromethane; water; acetic anhydride; acetone;
DOI:10.1055/s-1993-26039