156589-18-3Relevant academic research and scientific papers
2-(4-acetyl-2-nitrophenyl)ethyl: A new base-labile carboxyl protecting group
Robles,Pedroso,Grandas
, p. 1261 - 1266 (2007/10/02)
A new base-labile carboxyl protecting group, the 2-(4-acetyl-2-nitrophenyl)ethyl (Anpe) group is reported and compared with other base-labile protecting groups. The synthesis of the alcohol precursor, 1-[4-(2-hydroxyethyl)-3-nitrophenyl]-1-ethanone, the amino acid derivatives Boc-Asp(Anpe)-OH and Boc-Glu(Anpe)-OH and the conditions under which the carboxyl protecting group can be eliminated are also described.
