(2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

Base Information

Chemical Name:(2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester
CAS No.:1093190-63-6
Molecular Formula:C₂₈H₃₇N₃O₅
Molecular Weight:495.619
Hs Code.:

Synonyms:(2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

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Chemical Property of (2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

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Technology Process of (2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

There total 5 articles about (2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 4-(4-(4-morrpholin-4-ylmethylphenyl)piperidin-1-yl)benzoic acid dihydrochloride

: 39994-75-7
L-threonine methyl ester hydrochloride

: 1093190-63-6
(2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

Guidance literature:: 4-(4-(4-morrpholin-4-ylmethylphenyl)piperidin-1-yl)benzoic acid dihydrochloride; With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

L-threonine methyl ester hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 864359-18-2
tert-butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate

: 1093190-63-6
(2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: 4 A molecular sieve; copper diacetate; triethylamine / 1,2-dichloro-ethane / 20 °C

4.1: sodium hydroxide; water / 1,4-dioxane / 20 °C

4.2: pH ~ 2

5.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 20 °C

With sodium hydroxide; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4 A molecular sieve; water; copper diacetate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 4-(4-piperidin-4-ylbenzyl)morrpholine dihydrochloride

: 1093190-63-6
(2S,3R)-3-hydroxy-2-(4-(4-(4-morpholin-4-ylmethylphenyl)piperidin-1-yl)benzoylamino)butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 A molecular sieve; copper diacetate; triethylamine / 1,2-dichloro-ethane / 20 °C

2.1: sodium hydroxide; water / 1,4-dioxane / 20 °C

2.2: pH ~ 2

3.1: O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

With sodium hydroxide; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4 A molecular sieve; water; copper diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;