1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Base Information

Chemical Name:1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide
CAS No.:1207203-63-1
Molecular Formula:C₃₇H₃₈ClFN₂O₅S
Molecular Weight:677.237
Hs Code.:

Synonyms:1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

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Chemical Property of 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

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Technology Process of 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

There total 11 articles about 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56243-25-5
1-benzyl-4-cyano-4-phenylpiperidine

: 1207203-63-1
1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sulfuric acid / 1 h / 100 °C

1.2: Cooling with ice

2.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C

With sulfuric acid; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 1207203-62-0
5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylic acid

: 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride

: 1207203-63-1
1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 59084-07-0
1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide; hydrochloride

: 1207203-63-1
1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yl oxy)prop oxy]phenyl}thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;