4-Bromo-3-methoxyphenol

Base Information

• Chemical Name: 4-Bromo-3-methoxyphenol
• CAS No.: 102127-34-4
• Molecular Formula: C7H7BrO2
• Molecular Weight: 203.035
• Hs Code.: 29095000
• Mol file: 102127-34-4.mol

Synonyms:4-Bromo-5-methoxyphenol;NSC 406897;

Chemical Property of 4-Bromo-3-methoxyphenol

Chemical Property:

• Vapor Pressure: 0.00239mmHg at 25°C
• Melting Point: 75-78 °C
• Refractive Index: 1.578
• Boiling Point: 279.3 °C at 760 mmHg
• PKA: 9.02±0.18(Predicted)
• Flash Point: 122.7 °C
• PSA: 29.46000
• Density: 1.585 g/cm³
• LogP: 2.16330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-3-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-3-methoxyphenol

There total 14 articles about 4-Bromo-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-bromo-3-methoxyphenyl 4-methylbenzenesulfonate (137396-01-1) → 4-bromo-3-methoxyphenol (102127-34-4)

Guidance literature:

With sodium hydroxide; In methanol; for 1.5h; Heating;

DOI:10.1021/ja067710a

Reference yield: 81.0%

O-methylresorcine (150-19-6) → 2-bromo-5-methoxyphenol (63604-94-4) + 4-bromo-3-methoxyphenol (102127-34-4)

Guidance literature:

With N-Bromosuccinimide; In carbon disulfide; for 1h; Ambient temperature;

DOI:10.1055/s-1997-1553

Reference yield: 75.0%

O-methylresorcine (150-19-6) → 4-bromo-3-methoxyphenol (102127-34-4)

Guidance literature:

With (Bu₄N)₂S₂O₈; lithium bromide; In acetonitrile; at 25 ℃; for 8h;

DOI:10.1016/j.tetlet.2004.04.112 DOI:10.1080/10426500590911395

upstream raw materials:

5-bromo-2-hydroxy-4-methoxybenzoic acid

4-bromo-3-methoxyphenyl 4-methylbenzenesulfonate

O-methylresorcine

water

Downstream raw materials:

1-bromo-4-isopropoxy-2-methoxybenzene

4-bromo-3-methoxyphenyl acetate

4-benzyloxy-1-bromo-2-methoxybenzene

2-[2-(4-Acetoxy-2-methoxy-phenyl)-2-oxo-eth-(Z)-ylidene]-pentanoic acid methyl ester

Refernces

• 1、 Park, Min Young,Yang, Seung Gak,Jadhav, Vidyadhar,Kim, Yong Hae. "Practical and regioselective brominations of aromatic compounds using tetrabutylammonium peroxydisulfate". . p. 4887 - 4890. Retrieved 2004.
• 2、 Min, Young Park,Seung, Gak Yang,Kim, Yong Hae. "Practical and regioselective halogenations of aromatic compounds using tetrabutylammonium peroxydisulfate". . p. 1235 - 1240. Retrieved 2005.
• 3、 Fan, Jiali,Wei, Qiancheng,Zhu, Ershu,Gao, Jing,Cheng, Xiamin,Lu, Yongna,Loh, Teck-Peng. "Visible light-induced mono-bromination of arenes with BrCCl3". supporting information. p. 5977 - 5980. Retrieved 2021/06/18.
• 4、 Chen, Xiaohong,Liu, Xiaoguang,Martinez, Jenny S.,Mohr, Justin T.. "Practical regioselective halogenation of vinylogous esters: Synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols". . p. 3653 - 3665. Retrieved 2016/06/06.