tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate
CAS No.:1402047-79-3
Molecular Formula:C₁₈H₂₅F₃N₂O₂
Molecular Weight:358.404
Hs Code.:

Synonyms:tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1402047-78-2
C₁₇H₂₄N₂O₂

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1402047-79-3
tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

Guidance literature:: With potassium hydrogen fluoride; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201204481

Reference yield:

: 100-46-9
benzylamine

: 1402047-79-3
tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 5 h / Reflux; Inert atmosphere

2: potassium hydrogen fluoride; trifluoroacetic acid / acetonitrile; N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With potassium hydrogen fluoride; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/anie.201204481

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1402047-79-3
tert-butyl 4-(benzylamino)-4-(trifluoromethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 5 h / Reflux; Inert atmosphere

2: potassium hydrogen fluoride; trifluoroacetic acid / acetonitrile; N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With potassium hydrogen fluoride; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1002/anie.201204481