(S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester
CAS No.:219585-90-7
Molecular Formula:C₂₀H₂₉NO₄
Molecular Weight:347.455
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 145452-11-5
(S)-2-Amino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

: 219585-90-7
(S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/ol0059293

Reference yield: 98.0%

: 219585-90-7
(S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

: 219585-99-6
(S)-2-Benzyloxycarbonylamino-4-methyl-2-(2-oxo-ethyl)-pentanoic acid methyl ester

Guidance literature:: With ozone; triphenylphosphine;
DOI:10.1021/ja982973t

Reference yield:

: 219585-90-7
(S)-2-Benzyloxycarbonylamino-2-isobutyl-5-methyl-hex-4-enoic acid methyl ester

: 219585-92-9
(2S,5'S)-5'-[2-Hydroxy-3-(toluene-4-sulfonyloxy)-propyl]-2,5'-diisobutyl-4-[(R)-3-methyl-1-(2-trimethylsilanyl-ethoxymethoxymethyl)-butyl]-3,4'-dioxo-2,3,4',5'-tetrahydro-[2,3']bipyrrolyl-1,1'-dicarboxylic acid diallyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / O₃, Ph₃P

2: 94 percent / TsOH / methanol / Heating

3: 99 percent / cyclohexene / 10percent Pd/C / ethanol / Heating

4: benzene

5: KHMDS / tetrahydrofuran

6: 80 percent / TsOH / tetrahydrofuran; H₂O

7: benzene

8: KHMDS / tetrahydrofuran

9: 1.) KHMDS / 1.) THF, -78 deg C

10: 76 percent / TsOH, HOAc / methanol / 35 °C

11: 87 percent / Et₃N / CH₂Cl₂ / 0 °C

With potassium hexamethylsilazane; toluene-4-sulfonic acid; ozone; acetic acid; triethylamine; triphenylphosphine; cyclohexene; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene;
DOI:10.1021/ja982973t