(S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

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Chemical Name:(S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester
CAS No.:134996-53-5
Molecular Formula:C₃₀H₄₀N₂O₇S
Molecular Weight:572.723
Hs Code.:

Synonyms:(S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

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Chemical Property of (S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

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Technology Process of (S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

There total 8 articles about (S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97147-24-5
2-(tert-butylsulfonyl)-2-propenyl bromide

: 134996-53-5
(S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaHCO₃ / 1.) Me₂CO, H₂O, reflux, 60 min, 2.) THF, 0 deg C, 1 h; room temperature, overnight

2: 70 percent / benzene / 0.5 h / Ambient temperature

3: 91 percent / TFA / CH₂Cl₂ / 2 h / Ambient temperature

4: 82 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

5: NaHCO₃ / CH₂Cl₂ / 0.25 h

With thionyl chloride; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; benzene;
DOI:10.1021/jo982141d

Reference yield:

: 134996-37-5
2-(tert-butylsulfonyl)-2-propenyl alcohol

: 134996-53-5
(S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) room temperature, overnight

2: 70 percent / benzene / 0.5 h / Ambient temperature

3: 91 percent / TFA / CH₂Cl₂ / 2 h / Ambient temperature

4: 82 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

5: NaHCO₃ / CH₂Cl₂ / 0.25 h

With thionyl chloride; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo982141d

Reference yield:

: 134996-38-6
2-(t-Butylsulfonyl)-2-propenyl Chloroformate

: 134996-53-5
(S)-4-Methyl-2-{(S)-2-[2-(2-methyl-propane-2-sulfonyl)-allyloxycarbonylamino]-3-phenyl-propionylamino}-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / benzene / 0.5 h / Ambient temperature

2: 91 percent / TFA / CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

4: NaHCO₃ / CH₂Cl₂ / 0.25 h

With thionyl chloride; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; benzene;
DOI:10.1021/jo982141d