tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate
CAS No.:1304495-10-0
Molecular Formula:C₄₅H₅₃N₅O₉
Molecular Weight:807.944
Hs Code.:

Synonyms:tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Suppliers and Price of tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

There total 5 articles about tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1304495-09-7
(R)-5-[2,3-bis(benzyloxy)benzamido]-2-[(tert-butoxycarbonyl)amino]pentanoic acid

: 1304495-08-6
(S)-2-amino-N-[1-(benzyloxy)-2-oxopiperidin-3-yl]acetamide trifluoroacetate

: 1304495-10-0
tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Guidance literature:: (R)-5-[2,3-bis(benzyloxy)benzamido]-2-[(tert-butoxycarbonyl)amino]pentanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

(S)-2-amino-N-[1-(benzyloxy)-2-oxopiperidin-3-yl]acetamide trifluoroacetate; With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.003

Reference yield:

: 1304495-06-4
tert-butyl (S)-[2-[[1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]carbamate

: 1304495-10-0
tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With triethylsilane; 1,1'-carbonyldiimidazole; In dichloromethane;
DOI:10.1016/j.tet.2011.03.003

Reference yield:

: 74272-78-9
2,3-dibenzyloxybenzoic acid

: 1304495-10-0
tert-butyl [(R)-1-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-[2,3-bis(benzyloxy)benzamido]-1-oxopentan-2-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: potassium hydrogencarbonate / tetrahydrofuran; water / 24 h / 20 °C / pH 8 / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With potassium hydrogencarbonate; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2011.03.003