N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

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Chemical Name:N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]
CAS No.:1304495-13-3
Molecular Formula:C₆₁H₆₁N₅O₁₀
Molecular Weight:1024.18
Hs Code.:

Synonyms:N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

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Chemical Property of N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

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Technology Process of N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

There total 9 articles about N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1304495-08-6
(S)-2-amino-N-[1-(benzyloxy)-2-oxopiperidin-3-yl]acetamide trifluoroacetate

: 238081-25-9
(R)-2,5-bis[2,3-bis(benzyloxy)benzamido]pentanoic acid

: 1304495-13-3
N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

Guidance literature:: (R)-2,5-bis[2,3-bis(benzyloxy)benzamido]pentanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

(S)-2-amino-N-[1-(benzyloxy)-2-oxopiperidin-3-yl]acetamide trifluoroacetate; With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.003

Reference yield:

: N-[(R)-4-amino-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentyl]-2,3-bis(benzyloxy)benzamide trifluoroacetate

: 96920-81-9
2,3-bis(benzyloxy)benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 1304495-13-3
N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

Guidance literature:: With triethylamine; In water; acetonitrile; at 20 ℃; for 40h; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.003

Reference yield:

: 74272-78-9
2,3-dibenzyloxybenzoic acid

: 1304495-13-3
N,N'-[(R)-5-[[2-[[(S)-1-(benzyloxy)-2-oxopiperidin-3-yl]amino]-2-oxoethyl]amino]-5-oxopentane-1,4-diyl]bis[2,3-bis(benzyloxy)benzamide]

Guidance literature:: Multi-step reaction with 5 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: potassium hydrogencarbonate / tetrahydrofuran; water / 24 h / 20 °C / pH 8 / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: triethylsilane / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / water; acetonitrile / 40 h / 20 °C / Inert atmosphere

With triethylsilane; potassium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2011.03.003