307532-01-0Relevant articles and documents
Synthesis of phenolic components of Grains of Paradise
Hattori, Hiroyuki,Mitsunaga,Clive, Derrick L.J.
, p. 1989 - 1991 (2019)
Two vanilloids, (5E)-8-(4-hydroxy-3-methoxyphenyl)oct-5-en-4-one (1) and 4-[3-hydroxydecyl]-2-methoxyphenol (2), isolated from the dried seeds of Grains of Paradise (Aframomum melegueta), were synthesized; the latter compound was made as the S-enantiomer and the material derived from the seeds was found to be a 1:1.7 mixture of the R and S isomers. The synthetic route used should allow the preparation of analogs having extended alkyl chains and consequently different lipophilicity, and 3, a homolog of 2, was also prepared.
ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
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Paragraph 274; 275; 278-280, (2016/09/26)
The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans a
ALKYNYL ALCOHOLS AND METHODS OF USE
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, (2015/03/13)
The invention relates to compounds of Formula (0): wherein Q, A1-A8, R4 and R5 and each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over- activation of NF-kB signaling is observed.
Total synthesis of (-)-muricatacin
González, Maria,Gándara, Zoila,Covelo, Berta,Gómez, Generosa,Fall, Yagamare
supporting information; experimental part, p. 5983 - 5986 (2011/11/29)
A total synthesis of (-)-muricatacin has been achieved using a commercially available starting material and our furan approach to oxacyclic systems, the proven scope of which is thus broadened.
Synthesis of enantiomerically pure 2,5-disubstituted 3-oxygenated tetrahydrofurans
Alvarez, Carla,Perez, Manuel,Zuniga, Andrea,Gomez, Generosa,Fall, Yagamare
experimental part, p. 3883 - 3890 (2010/12/25)
The synthesis of enantiomerically pure 2,5-disubstituted 3-oxygenated tetrahydrofurans has been achieved from cheap and commercially available l-malic acid. This method was used to prepare an advanced intermediate toward CMI-977, a promising candidate for the treatment of chronic asthma. Georg Thieme Verlag Stuttgart · New York.
Total synthesis of ( - )-spirangien A, an antimitotic polyketide isolated from the myxobacterium Sorangium Cellulosum
Paterson, Ian,Findlay, Alison D.,Noti, Christian
experimental part, p. 594 - 611 (2010/04/23)
An expedient first total synthesis of (-)-spirangien A, a potent cytotoxic and antifungal polyketide of myxobacterial origin, is described. By using a common 1,3-diol intermediate obtained by an efficient aldol-reduction sequence for installation of the C
Vanadium-catalyzed asymmetric oxidation of α-hydroxy esters using molecular oxygen as stoichiometric oxidant
Radosevich, Alexander T.,Musich, Christine,Toste, F. Dean
, p. 1090 - 1091 (2007/10/03)
A vanadium-catalyzed method for the oxidative kinetic resolution of α-hydroxyesters, using oxygen as the terminal oxidant, is described. The catalyst is generated in situ from vanadium(V) tri-iso-propoxyoxide in combination with a tridentate ligand derived from 3,5-di-tert-butylsalicylaldehyde and (S)-tert-leucinol. The reaction allows for the enantioselective synthesis of both aromatic and aliphatic secondary alcohols, including those containing olefins and alkynes. Copyright
