1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

Base Information

Chemical Name:1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one
CAS No.:1609655-09-5
Molecular Formula:C₂₀H₂₂F₃NO₃
Molecular Weight:381.395
Hs Code.:

Synonyms:1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

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Chemical Property of 1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

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Technology Process of 1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

There total 6 articles about 1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1609655-08-4
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

: 1609655-09-5
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; for 1h;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609655-09-5
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 16 h / 80 °C / Inert atmosphere

5: tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

6: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 1 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; Dess-Martin periodane; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; chloroform; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; 2: |Duff Aldehyde Synthesis / 4: |Suzuki Coupling;

Reference yield:

: 119646-68-3
3-bromo-5-tert-butyl-2-hydroxy-benzaldehyde

: 1609655-09-5
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 16 h / 80 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

4: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 1 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; diethyl ether; dichloromethane; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;