1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

Base Information

Chemical Name:1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol
CAS No.:1609655-08-4
Molecular Formula:C₂₀H₂₄F₃NO₃
Molecular Weight:383.411
Hs Code.:

Synonyms:1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

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Chemical Property of 1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

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Technology Process of 1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

There total 5 articles about 1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1609655-07-3
5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

: 75-16-1
methylmagnesium bromide

: 1609655-08-4
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.166667h; Inert atmosphere;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609655-08-4
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 16 h / 80 °C / Inert atmosphere

5: tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; diethyl ether; chloroform; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; 2: |Duff Aldehyde Synthesis / 4: |Suzuki Coupling;

Reference yield:

: 119646-68-3
3-bromo-5-tert-butyl-2-hydroxy-benzaldehyde

: 1609655-08-4
1-(5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 16 h / 80 °C / Inert atmosphere

3: tetrahydrofuran; diethyl ether / 0.17 h / -78 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In tetrahydrofuran; diethyl ether; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;