5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Base Information

Chemical Name:5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde
CAS No.:1609655-07-3
Molecular Formula:C₁₉H₂₀F₃NO₃
Molecular Weight:367.368
Hs Code.:

Synonyms:5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

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Chemical Property of 5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

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Technology Process of 5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

There total 4 articles about 5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 868662-36-6
6-(trifluoromethyl)-3-pyridinylboronic acid

: 1609655-06-2
3-bromo-5-(tert-butyl)-2-(methoxymethoxy)benzaldehyde

: 1609655-07-3
5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In monoethylene glycol diethyl ether; water; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 98-54-4
para-tert-butylphenol

: 1609655-07-3
5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere

2: trifluoroacetic acid / 22 h / 90 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 16 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium carbonate; potassium carbonate; trifluoroacetic acid; In tetrachloromethane; chloroform; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; 2: |Duff Aldehyde Synthesis / 4: |Suzuki Coupling;

Reference yield:

: 119646-68-3
3-bromo-5-tert-butyl-2-hydroxy-benzaldehyde

: 1609655-07-3
5-(tert-butyl)-2-(methoxymethoxy)-3-(6-(trifluoromethyl)pyridin-3-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 16 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;