phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

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Chemical Name:phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate
CAS No.:871339-75-2
Molecular Formula:C₂₉H₃₂F₆N₄O₄
Molecular Weight:614.588
Hs Code.:

Synonyms:phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

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Chemical Property of phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

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Technology Process of phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

There total 5 articles about phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 871339-74-1
1,1-dimethylethyl 4-{2-methyl-5-{[(phenylmethyl)oxy]carbonyl}-3-[(2-pyrrolidin-1-ylethyl)amino]phenyl}piperazine-1-carboxylate

: 407-25-0
trifluoroacetic anhydride

: 871339-75-2
phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

Guidance literature:: 1,1-dimethylethyl 4-{2-methyl-5-{[(phenylmethyl)oxy]carbonyl}-3-[(2-pyrrolidin-1-ylethyl)amino]phenyl}piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

trifluoroacetic anhydride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 871339-72-9
phenylmethyl 3,5-dibromo-4-methylbenzoate

: 871339-75-2
phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

3.2: 1.5 h / 0 - 20 °C

With caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;

Reference yield:

: 871339-73-0
1,1-dimethylethyl 4-(3-bromo-2-methyl-5-{[(phenylmethyl)oxy]carbonyl}phenyl)piperazine-1-carboxylate

: 871339-75-2
phenylmethyl 4-methyl-3-[(2-pyrrolidin-1-ylethyl)(trifluoroacetyl)amino]-5-[4-(trifluoroacetyl)piperazin-1-yl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 100 °C

2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

2.2: 1.5 h / 0 - 20 °C

With caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;