Technology Process of 2-[(2R,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-3,4-dihydro-2H-pyran-4-yl]acetaldehyde
There total 6 articles about 2-[(2R,3S,4S)-3-(benzyloxy)-2-(benzyloxymethyl)-3,4-dihydro-2H-pyran-4-yl]acetaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N-dimethyl-aniline;
In
nitrobenzene;
at 150 - 170 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.201301665
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: boron trifluoride diethyl etherate / benzene / 0 - 25 °C / Inert atmosphere
2.1: methanol; potassium carbonate / 3 h / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 1.33 h / 0 °C / Inert atmosphere
3.2: 25 °C / Inert atmosphere
4.1: sodium periodate; sodium hydrogencarbonate / methanol; water / 1 h / 25 °C / Inert atmosphere
5.1: diisopropylamine / benzene / 0.5 h / Inert atmosphere; Reflux
6.1: N,N-dimethyl-aniline / nitrobenzene / 150 - 170 °C / Inert atmosphere
With
methanol; sodium periodate; boron trifluoride diethyl etherate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; diisopropylamine;
In
tetrahydrofuran; methanol; water; nitrobenzene; benzene;
1.1: |Ferrier Carbohydrate Rearrangement / 6.1: |Claisen Rearrangement;
DOI:10.1002/ejoc.201301665
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol; potassium carbonate / 3 h / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 1.33 h / 0 °C / Inert atmosphere
2.2: 25 °C / Inert atmosphere
3.1: sodium periodate; sodium hydrogencarbonate / methanol; water / 1 h / 25 °C / Inert atmosphere
4.1: diisopropylamine / benzene / 0.5 h / Inert atmosphere; Reflux
5.1: N,N-dimethyl-aniline / nitrobenzene / 150 - 170 °C / Inert atmosphere
With
methanol; sodium periodate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-aniline; diisopropylamine;
In
tetrahydrofuran; methanol; water; nitrobenzene; benzene;
5.1: |Claisen Rearrangement;
DOI:10.1002/ejoc.201301665
