(S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole
CAS No.:1397716-76-5
Molecular Formula:C₁₇H₁₂F₆NOP
Molecular Weight:391.253
Hs Code.:

Synonyms:(S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

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Chemical Property of (S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

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Technology Process of (S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

There total 3 articles about (S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 321848-64-0,153233-81-9,191330-82-2
(4S)-2-(2-bromophenyl)-4-phenyl-4,5-dihydro-1,3-oxazole

: 1397716-76-5
(S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: (4S)-2-(2-bromophenyl)-4-phenyl-4,5-dihydro-1,3-oxazole; With sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 0.25h; Inert atmosphere;

With triphenyl phosphite; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; cyclohexane; at -100 - 20 ℃; for 1.33333h; Inert atmosphere;

(trifluoromethyl)trimethylsilane; Further stages;
DOI:10.1021/jo3011717

Reference yield:

: 88-65-3
2-bromobenzoic-acid

: 1397716-76-5
(S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 6 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: sec.-butyllithium / cyclohexane; diethyl ether / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.33 h / -100 - 20 °C / Inert atmosphere

With sec.-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; cyclohexane;
DOI:10.1021/jo3011717

Reference yield:

: 20989-17-7
(2S)-2-phenylglycinol

: 1397716-76-5
(S)-2-(2-(bis(trifluoromethyl)phosphino)phenyl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 6 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: sec.-butyllithium / cyclohexane; diethyl ether / 0.25 h / -78 °C / Inert atmosphere

2.2: 1.33 h / -100 - 20 °C / Inert atmosphere

With sec.-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; cyclohexane;
DOI:10.1021/jo3011717