ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

Base Information

Chemical Name:ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate
CAS No.:1435472-78-8
Molecular Formula:C₁₅H₂₀N₂O₅
Molecular Weight:308.334
Hs Code.:

Synonyms:ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

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Chemical Property of ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

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Technology Process of ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

There total 2 articles about ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60946-75-0
ethyl 3-oxo-3-(2,5-dimethoxyphenyl)propionate

: 1668-10-6
glycinamide hydrochloride

: 1435472-78-8
ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

Guidance literature:: glycinamide hydrochloride; With sodium methylate; In methanol; at 65 ℃; for 1h;

ethyl 3-oxo-3-(2,5-dimethoxyphenyl)propionate; With acetic acid; In methanol; at 50 ℃; for 16h; Reflux;

Reference yield:

: 2785-98-0
2,5-dimethoxybenzoic acid

: 1435472-78-8
ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium ethylate / tetrahydrofuran / 4 h / 45 °C

1.2: 23 h / 20 - 45 °C

1.3: 3 h / 20 °C

2.1: sodium methylate / 1 h / 65 °C

2.2: 16.5 h / 10 °C

With sodium methylate; magnesium ethylate; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.5b00963

Reference yield: 59.0%

: 2290-65-5
trimethylsilyl isothiocyanate

: 1435472-78-8
ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

: 1435467-38-1
2-[6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl]acetamide

Guidance literature:: trimethylsilyl isothiocyanate; ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate; With acetic acid butyl ester; for 16h; Reflux;

With sodium hydroxide; at 40 ℃;
DOI:10.1021/acs.jmedchem.5b00963