2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate

Base Information

• Chemical Name: 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate
• CAS No.: 109872-22-2
• Molecular Formula: C₁₆H₁₈N₂O₆
• Molecular Weight: 334.329
• Mol file: 109872-22-2.mol

Synonyms:2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate

Chemical Property of 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate

There total 3 articles about 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 2-(tert-butyloxycarbonylamino)benzoic acid (68790-38-5) → 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate (109872-22-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate (109872-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. 0.5 N NaOH / dioxane; acetonitrile / 8 h / Ambient temperature

2: 30 percent / WSC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/ja952220w

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2,5-dioxopyrrolidin-1-yl 2-(tert-butoxycarbonylamino)benzoate (109872-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / aq. 0.5 N NaOH / dioxane; acetonitrile / 8 h / Ambient temperature

2: 30 percent / WSC, DMAP / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1021/ja952220w

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

2-(tert-butyloxycarbonylamino)benzoic acid

di-tert-butyl dicarbonate

anthranilic acid

Downstream raw materials:

(2-hydrazinocarbonylphenyl)carbamic acid tert-butyl ester

(S)-6-(2-Amino-benzoylamino)-2-benzyloxycarbonylamino-hexanoic acid 4-nitro-benzyl ester

(S)-2-Benzyloxycarbonylamino-6-(2-tert-butoxycarbonylamino-benzoylamino)-hexanoic acid 4-nitro-benzyl ester