4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Base Information

Chemical Name:4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile
CAS No.:1554015-27-8
Molecular Formula:C₃₁H₃₈ClN₅OS
Molecular Weight:564.195
Hs Code.:

Synonyms:4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Suppliers and Price of 4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

There total 12 articles about 4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1554015-93-8
4-tert-butyl-2-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenylamino)thiazole-5-carbonitrile

: 1554015-27-8
4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Guidance literature:: 4-tert-butyl-2-(2-(4-chloro-7-methoxy-1'-neopentylspiro[indoline-3,4'-piperidine]-1-yl)phenylamino)thiazole-5-carbonitrile; With boron trichloride; tetra-(n-butyl)ammonium iodide; In dichloromethane; at -50 - 23 ℃; for 19h; Inert atmosphere;

With methanol; In dichloromethane; for 0.5h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1554015-27-8
4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4 h / 23 °C

2.1: Dess-Martin periodane / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / dichloromethane; water; 1,4-dioxane / 1 h / 0 °C

3.2: 1.5 h / 0 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / 16 h / -78 - 20 °C

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 110 °C / Microwave irradiation; Inert atmosphere

6.1: sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 110 °C / Inert atmosphere

7.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 19 h / -50 - 23 °C / Inert atmosphere

7.2: 0.5 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; caesium carbonate; Dess-Martin periodane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: 768290-38-6
ethyl 1-pivaloylpiperidine-4-carboxylate

: 1554015-27-8
4-tert-butyl-2-({2-[4-chloro-1'-neopentyl-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}amino)-1,3-thiazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate; ethanol / tetrahydrofuran / 0 - 20 °C

2.1: Dess-Martin periodane / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / dichloromethane; water; 1,4-dioxane / 1 h / 0 °C

3.2: 1.5 h / 0 °C

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane / 16 h / -78 - 20 °C

5.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 110 °C / Microwave irradiation; Inert atmosphere

6.1: sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 18 h / 110 °C / Inert atmosphere

7.1: tetra-(n-butyl)ammonium iodide; boron trichloride / dichloromethane / 19 h / -50 - 23 °C / Inert atmosphere

7.2: 0.5 h

With hydrogenchloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ethanol; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; caesium carbonate; Dess-Martin periodane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium bis(2-methoxyethoxy)aluminium dihydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;