N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide

Base Information

• Chemical Name: N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide
• CAS No.: 152912-12-4
• Molecular Formula: C₁₉H₂₁Cl₂NO₂
• Molecular Weight: 366.287

Synonyms:N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide

Chemical Property of N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide

Chemical Property:

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Technology Process of N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide

There total 2 articles about N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethylbutanoic acid chloride (7065-46-5) + 2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol (74067-45-1) → N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide (152912-12-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(01)00290-5

Reference yield:

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone (2958-36-3,53960-29-5) → N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide (152912-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol

2: NaHCO₃ / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; In ethanol; dichloromethane;

DOI:10.1016/S0968-0896(01)00290-5

Reference yield: 83.0%

N-{4-chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-3,3-dimethyl-butyramide (152912-12-4) → [5-chloro-2-(3,3-dimethyl-butylamino)-phenyl]-(2-chloro-phenyl)-methanol (152910-47-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃;

DOI:10.1016/S0968-0896(01)00290-5

upstream raw materials:

3,3-dimethylbutanoic acid chloride

2-amino-5-chloro-α-(2'-chlorophenyl)benzyl alcohol

(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone

Downstream raw materials:

[5-chloro-2-(3,3-dimethyl-butylamino)-phenyl]-(2-chloro-phenyl)-methanol

(E)-3-[{4-Chloro-2-[(2-chloro-phenyl)-hydroxy-methyl]-phenyl}-(3,3-dimethyl-butyl)-carbamoyl]-acrylic acid ethyl ester

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