tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt

Base Information

• Chemical Name: tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt
• CAS No.: 115967-23-2
• Molecular Formula: C₂₃H₃₃N₂O₁₁S*Na
• Molecular Weight: 568.578
• Mol file: 115967-23-2.mol

Synonyms:tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt

Chemical Property of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt

There total 3 articles about tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosine α-methyl ester sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-tyrosine α-methyl ester (115967-22-1) → tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosine α-methyl ester sodium salt (115967-23-2)

Guidance literature:

With pyridinium acetyl sulfate; In pyridine; N,N-dimethyl-formamide; at 40 ℃; for 20h;

Reference yield:

Boc-Asp(OtBu)-OH (1676-90-0) → tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosine α-methyl ester sodium salt (115967-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / DCC, hydroxybenzotriazole / dimethylformamide / 1) -10 to -5 deg C, 2 h; 2) r.t., overnight

2: 84 percent / pyridinium acetyl sulfate / dimethylformamide; pyridine / 20 h / 40 °C

With benzotriazol-1-ol; pyridinium acetyl sulfate; dicyclohexyl-carbodiimide; In pyridine; N,N-dimethyl-formamide;

Reference yield:

L-Tyr-OMe (1080-06-4) → tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosine α-methyl ester sodium salt (115967-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / DCC, hydroxybenzotriazole / dimethylformamide / 1) -10 to -5 deg C, 2 h; 2) r.t., overnight

2: 84 percent / pyridinium acetyl sulfate / dimethylformamide; pyridine / 20 h / 40 °C

With benzotriazol-1-ol; pyridinium acetyl sulfate; dicyclohexyl-carbodiimide; In pyridine; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-tyrosine α-methyl ester

L-Tyr-OMe

Boc-Asp(OtBu)-OH

Downstream raw materials:

C₆₀H₇₉N₁₁O₁₉S₃^(2-)*2Na⁽¹⁺⁾

tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O⁴-sulfotyrosyl-methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide disodium salt

C₆₁H₈₀N₁₀O₁₈S₃^(2-)*2Na⁽¹⁺⁾

CCK-8