(E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester

Base Information

• Chemical Name: (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester
• CAS No.: 1607822-62-7
• Molecular Formula: C₂₁H₁₉F₃N₂O₄S
• Molecular Weight: 452.454
• Mol file: 1607822-62-7.mol

Synonyms:(E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester

Chemical Property of (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester

There total 4 articles about (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

methyl N-(2-bromomethylphenyl)-N-methoxy-carbamate (151827-83-7) + (E)-1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)-ethanoneoxime (1607822-48-9) → (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester (1607822-62-7)

Guidance literature:

With potassium carbonate; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2014.03.024

Reference yield:

2-(ethylthio)-5-trifluoromethyl-benzaldehyde (1186033-48-6) → (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester (1607822-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: calcium oxide / acetone / 59 °C

2: hydroxylamine hydrochloride; sodium acetate / water; ethanol / Reflux

3: potassium carbonate / acetonitrile / Reflux

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; calcium oxide; In ethanol; water; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2014.03.024

Reference yield:

2-chloro-5-(trifluoromethyl)benzaldehyde (82386-89-8) → (E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester (1607822-62-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / water / 0.5 h / 20 °C

1.2: 82 °C

2.1: calcium oxide / acetone / 59 °C

3.1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / Reflux

4.1: potassium carbonate / acetonitrile / Reflux

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; sodium hydroxide; calcium oxide; In ethanol; water; acetone; acetonitrile;

DOI:10.1016/j.bmcl.2014.03.024

upstream raw materials:

methyl N-(2-bromomethylphenyl)-N-methoxy-carbamate

(E)-1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)-ethanoneoxime

2-(ethylthio)-5-trifluoromethyl-benzaldehyde

2-chloro-5-(trifluoromethyl)benzaldehyde

Downstream raw materials:

(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea