(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

Base Information

Chemical Name:(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea
CAS No.:1607822-70-7
Molecular Formula:C₂₁H₂₀F₃N₃O₃S
Molecular Weight:451.469
Hs Code.:

Synonyms:(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

Suppliers and Price of (E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

There total 5 articles about (E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.7%

: 1607822-62-7
(E)-N-methoxy-N-(2-((5-trifluoromethyl-1-(1H-benzo[b]thien-2-yl)ethylidene)aminooxymethyl)phenyl)carbamic acid methyl ester

: 74-89-5
methylamine

: 1607822-70-7
(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

Guidance literature:: In methanol; Reflux;
DOI:10.1016/j.bmcl.2014.03.024

Reference yield:

: 82386-89-8
2-chloro-5-(trifluoromethyl)benzaldehyde

: 1607822-70-7
(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 0.5 h / 20 °C

1.2: 82 °C

2.1: calcium oxide / acetone / 59 °C

3.1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / Reflux

4.1: potassium carbonate / acetonitrile / Reflux

5.1: methanol / Reflux

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; sodium hydroxide; calcium oxide; In methanol; ethanol; water; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2014.03.024

Reference yield:

: 1186033-48-6
2-(ethylthio)-5-trifluoromethyl-benzaldehyde

: 1607822-70-7
(E)-1-methoxy-3-methyl-1-(2-((((1-(5-trifluoromethyl-1H-benzo[b]thien-2-yl)ethylidene)amino)oxy)methyl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: calcium oxide / acetone / 59 °C

2: hydroxylamine hydrochloride; sodium acetate / water; ethanol / Reflux

3: potassium carbonate / acetonitrile / Reflux

4: methanol / Reflux

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; calcium oxide; In methanol; ethanol; water; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2014.03.024