82386-89-8

Basic information

• Product Name: 2-Chloro-5-trifluoromethylbenzaldehyde
• Synonyms: TIMTEC-BB SBB003466;2-CHLORO-5-(TRIFLUOROMETHYL)BENZALDEHYDE;2-Chloro-5-(trifluoromethyl)benzaldehyde, 97+%;2-Chloro-5-(trifluoromethyl)benzaldehyde98%;4-Chloro-3-formylbenzotrifluoride;4-Chloro-3-formylbenzotrifluoride, 6-Chloro-alpha,alpha,alpha-trifluoro-m-tolualdehyde;2-Chloro-5-(trifluoroMethyl)benzaldehyde, 95+%
• CAS NO: 82386-89-8
• Molecular Formula: C₈H₄ClF₃O
• Molecular Weight: 208.56
• Product Categories: Fluorobenzene;Carbonyl Compounds;Benzaldehyde;Aldehydes;C8;Carbonyl Compounds;Fluorine series
• Mol File: 82386-89-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 42-44 °C1.5 mm Hg(lit.)
• Flash Point: 193 °F
• Appearance: clear, colorless to pale yellow liquid
• Density: 1.435 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.453mmHg at 25°C
• Refractive Index: n20/D 1.488(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Chloro-5-trifluoromethylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-trifluoromethylbenzaldehyde(82386-89-8)
• EPA Substance Registry System: 2-Chloro-5-trifluoromethylbenzaldehyde(82386-89-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 82386-89-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

2-Chloro-5-(trifluoromethyl)benzaldehyde may be used as reactant in the three-component reaction of 2-halogenated aromatic aldehydes, 1H-benzo[d]imidazol-5-amine and cyclohexane-1,3-diones to afford imidazoquinolinoacridinone derivatives. It may be used in the gas-phase chemical derivatization of poly(tetrafluoroethylene) and poly(ethylene terephthalate) using gas plasma.

InChI:InChI=1/C8H4ClF3O/c9-7-2-1-6(8(10,11)12)3-5(7)4-13/h1-4H

Upstream product

• 64372-62-9 (2-chloro-5-(trifluoromethyl)phenyl)methanol 
• 75-17-2 formaldoxime 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 
• 22902-87-0 1-chloro-2-(chloromethyl)-4-(trifluoromethyl)benzene 

Downstream Products

• 64372-62-9 (2-chloro-5-(trifluoromethyl)phenyl)methanol 
• 545410-66-0 2-chloro-5-trifluoromethylphenylethylene oxide 
• 912290-98-3 1-(2-chloro-5-trifluoromethylbenzyl)-piperidine hydrochloride 
• 912291-01-1 (2-chloro-5-trifluoromethylbenzyl)-[2-(1H-indol-3-yl)-ethyl]-amine hydrochloride 
• 1392144-16-9 C₂₉H₂₅F₃N₄O₄S₂ 
• 931112-50-4 6-(5-chloro-2-hydroxyphenyl)-4-(2-chloro-5-(trifluoromethyl)phenyl)-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 912290-86-9 (2-chloro-5-trifluoromethylbenzyl)-methyl-amine hydrochloride 
• 912290-91-6 (2-chloro-5-trifluoromethylbenzyl)-dimethyl-amine hydrochloride 
• 912291-02-2 (2-chloro-5-trifluoromethylbenzyl)-furan-2-ylmethyl-amine hydrochloride 
• 84884-39-9 5-trifluoromethyl-2-phenylthio-α-(1-methyl-4-piperidyl)benzyl alcohol 

Relevant articles and documents

Practical Cu(OAc)2/TEMPO-catalyzed selective aerobic alcohol oxidation under ambient conditions in aqueous acetonitrile

We reported a ligand-and additive-free Cu(OAc)2/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary and secondary benzylic alcohols, primary and secondary 1-heteroaryl alcohols, cinnamyl alcohols, and aliphatic alcohols to the corresponding aldehydes and ketones. This ambient temperature oxidation protocol is of practical features like aqueous acetonitrile as solvent, ambient air as the terminal oxidant, and low catalyst loading, presenting a potential value in terms of both economical and environmental considerations. Based on the experimental observations, a plausible reaction mechanism was proposed.

Tricyclic psychotropic agents containing two chalcogen atoms in the central ring: Derivatives of 11H-dibenz[b,f]-1,4-oxathiepin

-