1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

Base Information

Chemical Name:1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid
CAS No.:273378-16-8
Molecular Formula:C17H29 N O4
Molecular Weight:311.422
Hs Code.:29333990
DSSTox Substance ID:DTXSID60589220
Wikidata:Q82482459
Mol file:273378-16-8.mol

Synonyms:273378-16-8;1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid;Boc-4-cyclohexyl-piperidine-4-carboxylic acid;4-Cyclohexyl-1,4-piperidinedicarboxylic Acid tert-Butyl Ester;4-cyclohexyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid;C17H29NO4;SCHEMBL4609802;DTXSID60589220;JGHJZAWKPOYZNI-UHFFFAOYSA-N;1-(tert-Butoxycarbonyl)-4-cyclohexyl-4-piperidinecarboxylic acid;1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylicacid;MFCD08457834;AKOS015999076;AS-47897;DA-07439;CS-0054929;F16724;N-Boc-4-cyclohexyl-4-piperidinecarboxylic acid;n-boc-4-cyclohexyl-4-piperidine-carboxylic acid;A876964;J-016740

Suppliers and Price of 1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Boc-4-cyclohexyl-piperidine-4-carboxylic acid
500mg
$ 355.00

TRC
4-Cyclohexyl-1,4-piperidinedicarboxylicAcidtert-ButylEster
250mg
$ 155.00

TRC
4-Cyclohexyl-1,4-piperidinedicarboxylicAcidtert-ButylEster
2.5g
$ 1230.00

Matrix Scientific
1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid 95+%
5g
$ 945.00

Matrix Scientific
1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid 95+%
1g
$ 336.00

Matrix Scientific
1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid 95+%
250mg
$ 152.00

Crysdot
1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylicacid 95+%
1g
$ 144.00

Crysdot
1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylicacid 95+%
5g
$ 653.00

Chemenu
1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylicacid 95%
5g
$ 617.00

Biosynth Carbosynth
Boc-4-cyclohexyl-piperidine-4-carboxylic acid
2 g
$ 340.00

Total 17 raw suppliers

Chemical Property of 1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

Chemical Property:

Vapor Pressure:7.68E-09mmHg at 25°C
Boiling Point:436.5°C at 760 mmHg
PKA:4.60±0.20(Predicted)
Flash Point:217.8°C
PSA：66.84000
Density:1.13g/cm³
LogP:3.60650
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:311.20965841
Heavy Atom Count:22
Complexity:413

Purity/Quality:

97% ^*data from raw suppliers

Boc-4-cyclohexyl-piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)(C2CCCCC2)C(=O)O
Uses A piperidine derivative as melanocortin 4 receptor agonists and their pharmaceutical compositions for treatment of obesity, excessive appetite, sexual dysfunction, and infertility.

Technology Process of 1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

There total 4 articles about 1-(tert-Butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 167262-68-2
N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid

: 273378-16-8
(1-tert-butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

Guidance literature:: With hydrogen; 5% rhodium on alumina; In ethanol; at 60 ℃; for 20h; under 4500.45 Torr;

Reference yield:

: 674791-75-4
C₇H₈O₃S*C₁₂H₂₁NO₂

: 24424-99-5
di-tert-butyl dicarbonate

: 75-64-9
tert-butylamine

: 273378-16-8
(1-tert-butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

Guidance literature:: C₇H₈O₃S*C₁₂H₂₁NO₂; di-tert-butyl dicarbonate; With sodium hydroxide; In tetrahydrofuran; water; at 10 - 17 ℃; for 2h;

tert-butylamine; With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; pH=12;

With hydrogenchloride; In water;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 273378-16-8
(1-tert-butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / dioxane

2: H₂ / Rh/Al₂O₃ / methanol / 70 °C / 3620.04 Torr

With sodium hydroxide; hydrogen; Rh/Al₂O₃; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2004.10.020