fluoro-(D)-Phe,t-butyl amide dipeptide

Base Information

Chemical Name:fluoro-(D)-Phe,t-butyl amide dipeptide
CAS No.:674792-27-9
Molecular Formula:C₂₅H₃₈FN₃O₂*ClH
Molecular Weight:468.055
Hs Code.:

Synonyms:fluoro-(D)-Phe,t-butyl amide dipeptide

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Chemical Property of fluoro-(D)-Phe,t-butyl amide dipeptide

Chemical Property:

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Technology Process of fluoro-(D)-Phe,t-butyl amide dipeptide

There total 5 articles about fluoro-(D)-Phe,t-butyl amide dipeptide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 363191-03-1
[(1R)-2-[4-Cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]carbamic Acid 1,1-dimethylethyl Ester

: 674792-27-9
fluoro-(D)-Phe,t-butyl amide dipeptide

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.bmcl.2011.02.090

Reference yield:

: 273378-16-8
(1-tert-butoxycarbonyl)-4-cyclohexylpiperidine-4-carboxylic acid

: 674792-27-9
fluoro-(D)-Phe,t-butyl amide dipeptide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / Rh/Al₂O₃ / methanol / 8 h / 70 °C / 3620.13 Torr

1.2: 18.75 h / 0 - 20 °C

2.1: potassium carbonate / methyltertbutyl ether; water / 4 h

2.2: 4 h / 40 - 45 °C

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0.17 h

3.2: 2.5 h / 20 °C

4.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 2 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Rh/Al₂O₃; In methanol; methyltertbutyl ether; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 674791-75-4
C₇H₈O₃S*C₁₂H₂₁NO₂

: 674792-27-9
fluoro-(D)-Phe,t-butyl amide dipeptide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 2 h / 10 - 17 °C

1.2: 0 - 20 °C / pH 12

2.1: hydrogen / Rh/Al₂O₃ / methanol / 8 h / 70 °C / 3620.13 Torr

2.2: 18.75 h / 0 - 20 °C

3.1: potassium carbonate / methyltertbutyl ether; water / 4 h

3.2: 4 h / 40 - 45 °C

4.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0.17 h

4.2: 2.5 h / 20 °C

5.1: hydrogenchloride / dichloromethane; isopropyl alcohol / 2 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Rh/Al₂O₃; In tetrahydrofuran; methanol; methyltertbutyl ether; dichloromethane; water; isopropyl alcohol; acetonitrile;