Leu-Pro-Phe-Phe-Asp

Base Information

Chemical Name:Leu-Pro-Phe-Phe-Asp
CAS No.:182912-74-9
Molecular Formula:C33H43 N5 O8
Molecular Weight:637.733
Hs Code.:
DSSTox Substance ID:DTXSID00436123
Nikkaji Number:J1.909.425A
Wikidata:Q82251336
Mol file:182912-74-9.mol

Synonyms:182912-74-9;Leu-Pro-Phe-Phe-Asp;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]butanedioic acid;LPFFD;(PRO18,ASP21)-AMYLOID BETA-PROTEIN (17-21);Beta-Sheet Breaker Peptide iA|A5;Beta-Sheet Breaker Peptide iA5;DTXSID00436123;RALAXQOLLAQGTI-IRGGMKSGSA-N;HY-P1047;PD163358;CS-0025317;L-Aspartic acid,L-leucyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-

Suppliers and Price of Leu-Pro-Phe-Phe-Asp

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ApexBio Technology
Beta-SheetBreakerPeptideiAβ5
25mg
$ 105.00

ApexBio Technology
Beta-SheetBreakerPeptideiAβ5
10mg
$ 75.00

ApexBio Technology
Beta-SheetBreakerPeptideiAβ5
5mg
$ 45.00

American Custom Chemicals Corporation
[PRO18,ASP21]BETA-AMYLOID(17-21),IAB5 95.00%
1MG
$ 588.19

Total 13 raw suppliers

Chemical Property of Leu-Pro-Phe-Phe-Asp

Chemical Property:

Boiling Point:980.0±65.0 °C(Predicted)
PKA:2.88±0.10(Predicted)
PSA：208.23000
Density:1.291±0.06 g/cm3(Predicted)
LogP:2.66080
Storage Temp.:−20°C
Solubility.:≥63.7 mg/mL in DMSO; ≥16.33 mg/mL in EtOH; ≥6.9 mg/mL in H2O with ultrasonic
XLogP3:-1.5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:16
Exact Mass:637.31116335
Heavy Atom Count:46
Complexity:1070

Purity/Quality:

99%, ^*data from raw suppliers

Beta-SheetBreakerPeptideiAβ5 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(=O)O)C(=O)O)N
Isomeric SMILES:CC(C)C[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC(=O)O)C(=O)O)N

Technology Process of Leu-Pro-Phe-Phe-Asp

There total 2 articles about Leu-Pro-Phe-Phe-Asp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: C₁₀₃H₁₇₃N₅O₁₃

: 182912-74-9
LPFFD

Guidance literature:: With trifluoroacetic acid; In water; at 20 ℃; for 1h;
DOI:10.1021/acs.orglett.5b02057

Reference yield:

: Fmoc-Asp(tBu)-PEG-polystyrene resin

: 35661-60-0
Fmoc-Leu-OH

: 71989-31-6
Fmoc-Pro-OH

: 35661-40-6
N-Fmoc L-Phe

: 182912-74-9
LPFFD

Guidance literature:: Fmoc-Asp(tBu)-PEG-polystyrene resin; solid phase reaction;

solid phase reaction;

Fmoc-Leu-OH; Fmoc-Pro-OH; N-Fmoc L-Phe; Further stages;
DOI:10.1016/j.peptides.2010.06.033